1-(2-Chlorophenyl)-3-(2-ethylhexanoyl)thiourea

E ) - 1 - ( 2 - Aminophenyl ) - 3 - ( 4 - chlorophenyl ) prop - 2 - en - 1 - one

The title chalcone (E)-1-(2-aminophenyl)-3-(4-chlorophenyl)prop-2-en-1-one was prepared with an excellent yield from a Claisen–Schmidt condensation reaction between o-aminoacetophenone and p-chlorobenzaldehyde. This product will be used as a key precursor for the development of an alternative route for the total synthesis of dubamine and graveoline alkaloids. Single crystals of the title compou...

Ethyl 6-r-(2-chlorophenyl)-2-oxo-4-phenyl­cyclohex-3-ene-1-t-carboxylate

In the title mol-ecule, C(21)H(19)ClO(3), the cyclo-hexene ring adopts an envelope conformation, with all substituents equatorial. The plane through its five coplanar atoms makes dihedral angles of 12.75 (14) and 74.16 (8)° with the phenyl and benzene rings, respectively. The dihedral angle between the latter two rings is 81.73 (12)°. Inter-molecular C-H⋯O hydrogen bonds and intra-molecular C-H...

Inhibition of hepatic lipid biosynthesis by 1-(3-chlorophenyl)-1-methyl-2-phenyl-2-(2-pyridine) ethanol, a hypocholesterolemic agent.

1. G. J. Dutton and B. Burchell, Prog. Drug. Metab. 2, 1 (1977). 2. C. H. Gunn, J, Hered. 29, 137 (1938). 3. G. A. Lathe and M. Walker, Biochem. J. 67, 9P (1957). 4. J. Carbone and G. M. Grodsky, Proc. Soc. exp. biol. Med. 94, 449 (1957). 5. R. Schmid, J. Axelrod, L. Hammaker and R. L. Swarm, J. clin. Invest. 37, 1123 (1958). 6. I. M. Arias, Biochem. biophys. Res. Commun. 6, 81 (1961). 7. I. H....

Methyl 3-(2-chlorophenyl)-2-(1H-indol-3-ylmethyl)-5-[1-(4-methoxyphenyl)-4-oxo-3-phenylazetidin-2-yl]-4-nitropyr­rolidine-2-carboxylate

In the mol-ecule of the title compound, C(37)H(33)ClN(4)O(6), the four-membered β-lactam ring is essentially planar and is oriented at dihedral angles of 30.0 (1), 76.3 (1) and 30.9 (1)° with respect to the methoxy-phenyl ring, the phenyl ring and the indole unit, respectively. The pyrrolidine ring adopts a twist conformation. Intra-molecular C-H⋯Cl and C-H⋯O hydrogen bonds result in the format...

1:1:1-Trichloro-2:2-di-(p-chlorophenyl)ethane (DDT) and rat adipose tissue.